Comparing the anti-inflammatory effect between topical dexamethasone versus intracameral triamcinolone acetonide after phacoemulsification

Authors

  • Minahil Afzal Shalamar Hospital Lahore, Pakistan Author
  • Minahil Naul Shalamar Hospital Lahore, Pakistan Author
  • Zainab Hussain Shalamar Hospital Lahore, Pakistan Author
  • Muhammad Sher Zaman Government Collage University, Faiasalabad, Pakistan Author

DOI:

https://doi.org/10.61581/d1707r83

Abstract

Objective: is to compare the effectiveness of intracameral triamcinolone acetonide injection and topical dexamethasone in the prevention of postoperative inflammation after phacoemulsification.

Methodology: Randomized controlled trial at department of Opthalmology and Shalamar Hospital, Lahore, from March 2021, to February, 2022. Total number of patients (80) were assigned in two group on basis of their treatment plan either topical dexamethasone or triamcinolone intracameral. Main variables of study were postoperative outcomes (cells or flare) and intraocular pressure at day 1, 7 and 28.

Results: Postoperative outcomes of Group A and Group B with respect to cells and flare were almost equal, (p>0.050). Further, the mean intraocular pressure at preoperative, day one, day seven and twenty-eight day in both the groups were almost equally distributed, and the differences were statistically insignificant, (p>0.050).

Conclusion: There was difference between intracameral injection of triamcinolone acetonide and topical dexamethasone in terms of postoperative inflammation and intraocular pressure after cataract surgery with phacoemulsification technique.

References

Elgazzar AF. Anti-inflammatory Effects of Intracameral Triamcinolone Acetonide Injection versus Topical Dexamethasone after Cataract Surgery: A Prospective Comparative Study Akram Fekry Elgazzar and Riad Elzaher Hassan Ahmed. Global J Curr Res Vol. 2019;6(4):149-53.

El-Haddad NS. A Single Dose Intracameral Triamcinolone Injection Following Phacoemulsification. The Egypt J Hospital Med. 2021;84(1):2667-70.

Murthy GVS, John N, ShamannaBR, Pant HB. Elimination of avoidable blindness due to cataract: Where do we prioritize and how should we monitor this decade? Ind J Ophhthalmol.2012; 60: 438-445.

Choopong P, Taetrongchit N, Boonsopon S, Nimkarn A, Srisukkosalin K, Chonpimai P et al. Efficacy of subtenon 20-mg triamcinolone injection versus 0.1% dexamethasone eye drops for controlling inflammation after phacoemulsification: a randomized controlled trial. Sci Reports. 2022;12(1):16471.

Khairallah M, Kahloun R, Bourne R, et al. Number of people blind or visually impaired by cataract worldwide and in world regions, 1990 to 2010. Invest Ophthalmol Vis Sci. 2015 Oct; 56 (11): 6762-9.

Khan MA, Ahmad F, Ahsen M, Anwar F, Shahzad MA, Bhatti SA. Examine the Comparison of Efficacy Between Intracameral and Sub Conjuctival Dexamethasone for the Prevention of Postoperative Inflammation in Patients with Cataract Surgery. Pak J Med Health Sci. 2022;16(05):1435-.1440.

Dayal SM, Rehman M, Abbas I. Effectiveness of intracameral and subconjunctival dexamethasone for prevention of postoperative inflammation in cataract surgery. Pak J Med Health Sci. 2021;15(3):583-5.

Waseem AM. Intracameral Versus Sub-conjunctival Dexamethasone Injection for Postoperative Inflammation in Congenital Cataract Surgery. Pak J Ophthalmol. 2019 Jul 1;35(3):123-34.

Grzybowski A, Sidaraite A, Zemaitiene R. Management of inflammation after the cataract surgery. Current Opinion in Ophthalmology. 2023;34(1):9-20.

Jamil AZ, Ahmed A, Mirza KA. Effect of intracameral use of Dexamethasone on corneal endothelial cells. Coll Phys Surg Pak. 2014; 24: 245-248.

Chen P, Han X, Zhu Y, Xu J. Comparison of antiinflammatory effects of flourometholone 0.1% combined with levofloxacin 0.5% and tobramycin/dexamethasone eye drops after cataract surgery. Int J Ophthalmol. 2016; 9 (11): 1619–1623.

Ellis PP. Pharmacological effects of corticosteroids. Int Ophthalmol Clin. 1996; 6: 799–819.

Simaroj P1, Sinsawad P, Lekhanont K. Effects of intracameral triamcinolone and gentamicin injections following cataract surgery. J Med Assoc Thai. 2011 Jul; 94: 819-25.

Oh JY, Wee WR, Lee JH, Kim MK. Short-term effect of intracameral triamcinolone acetonide on corneal endothelium using the rabbit model. Eye (Lond) 2007; 21: 812–8.

Chang YS, Tseng SY, Teseng SH, Wu CL, Chen MF. Triamcinolone acetonide suspension toxicity to corneal endothelial cells. J Cataract Refract Surg. 2006; 32: 1549– 55.

Gills JP, Gills P. Effect of intracameral triamcinolone to control inflammation following cataract surgery. J Cataract Refract Surg. 2005; 31: 1670–1.

Karalezli A, Borazan M, Akova YA. Intracameral triamcinolone acetonide to control postoperative inflammation following cataract surgery with Phacoemulsification. Acta Ophthalmol. 2008; 86: 183–7.

Manzoor A, Moin M. Comparison of Anti-inflammatory Effect between Intracameral Triamcinolone Acetonide and Topical Dexamethasone after Phacoemulsification. Pak J Opthalmol. 2018;34(1):19-24.

Dada T, Dhawan M, Garg S, Nair S. Safety and efficacy of intraoperative intravitreal injection of triamcinolone acetonide injection after phacoemulsification in cases of uveitic cataract. J Cataract Refract Surg. 2007; 33: 1613– 18.

Elkhodary NM, Hasan ZS, El-Din Mohamed NS. Comparison of Anti-inflammatory Effect between Intracameral Triamcinolone Acetonide and Topical Dexamethasone after Phacoemulsification. The Egyptian Journal of Hospital Medicine. 2023;90(1):601-6.

Downloads

Published

30-03-2023

How to Cite

Minahil Afzal, Minahil Naul, Zainab Hussain, & Muhammad Sher Zaman. (2023). Comparing the anti-inflammatory effect between topical dexamethasone versus intracameral triamcinolone acetonide after phacoemulsification. International Journal of Medical Scholars , 1(1), 12-17. https://doi.org/10.61581/d1707r83