Comparison of Prophylactic Use of Intravenous N Acetylcysteine v/s Amiodarone in Preventing Post Operative Artrial Fibrillation after Coronary Artery Bypass Graft

Abstract

Objective: compare the effectiveness of intravenous N-acetylcysteine and amiodarone in prevention of pos operative atrial fibrillation.

Study Design: Randomized control trial

Place and duration: study was conducted cardiac surgery department of Choudhary Pervaiz Elahi Institute of Cardiology, Multan from December 2017 to December 2018 in one year duration.

Methodology: study was conducted on 130 patients. Patients were divided into two equal groups by lottery method. Study was started after permission from academic affairs committee written informed consent from the patients. Non probability consecutive sampling was used Study variables are age, gender, duration of ICU stay and mortality. An outcome variable was post operative atrial fibrillation. Data was computed on software SPSS version 23 and analyzed for all possible variables. P value ?0.05 was taken as significant.

Results: POAF of amiodarone and NAC group was noted as 26.2% and 13.8%, respectively. The difference was statistically insignificant (0.079). Mortality of amiodarone and NAC groups was occurred as 7.7% and 4.6%, respectively. The difference was statistically insignificant (0.465).

Conclusion: intravenous N-acetylcysteine is more effective in prevention of post operative atrial fibrillation as compared intravenous amiodarone but post operative stay is prolonged in patients of NAC.